Sucralfate is a hydroxy aluminum salt of sucrose octasulfate that acts as a local mucosal adherent (in simple terms, it works by coating the stomach and small intestine with a protective layer, preventing ulcers forming and also allows existing ulcers to heal).
The absorption of sucralfate is minimal; its actions are local rather than systemic and it does not affect gastric-acid output or enzyme activity.
Sucralfate is used to on gastric ulcers and ulcers of the right dorsal colon in adult horses. Typically used with an H2 receptor antagonist or a proton-pump inhibitor such as omeprazole, sucralfate appears to provide significant pain relief in horses that show abdominal discomfort due to ulcers.
The content of this article should not be considered, or used as a substitute for, veterinary medical advice, diagnosis or treatment.