Sucralfate is a hydroxy aluminum salt of sucrose octasulfate that acts as a local mucosal adherent (in simple terms, it works by coating the stomach and small intestine with a protective layer, preventing ulcers forming and also allows existing ulcers to heal).

The absorption of sucralfate is minimal; its actions are local rather than systemic and it does not affect gastric-acid output or enzyme activity.

Sucralfate is used to on gastric ulcers and ulcers of the right dorsal colon in adult horses. Typically used with an H2 receptor antagonist or a proton-pump inhibitor such as omeprazole, sucralfate appears to provide significant pain relief in horses that show abdominal discomfort due to ulcers.